Ensure the highest standard of pharmaceutical-grade chemical supply with Leucovorin Calcium, USP, manufactured by Spectrum Chemical. This vital reagent, also known as Calcium Folinate, is a derivative of folic acid used extensively in biochemical research and pharmaceutical formulation. As a USP Grade material, it is manufactured under stringent quality controls and meets the specific monographs established by the United States Pharmacopeia, ensuring it is suitable for food, drug, or medicinal use.
Leucovorin Calcium is primarily utilized in research related to oncology and cellular metabolism, acting as a potent biochemical modulator to "rescue" cells from the effects of methotrexate or to potentiate the activity of fluorouracil.
Technical Specifications:
CAS Number: 1492-18-8
Molecular Formula: C20H21CaN7O7
Molecular Weight: 511.50 g/mol
Appearance: White to pale yellow crystalline powder
Solubility: Sparingly soluble in water; practically insoluble in alcohol
Storage: Store at controlled room temperature (20°C to 25°C), protected from light and moisture
Application Insight:
In the laboratory environment, Leucovorin Calcium is used as:
Folate Rescue Agent: To study the mechanisms of dihydrofolate reductase (DHFR) inhibition
Potentiating Agent: In colorectal cancer research to stabilize the binding of fluorodeoxyuridylate to thymidylate synthase
Standardization: As a reference standard for high-performance liquid chromatography (HPLC) and other analytical validation methods
Regulatory Note: This product is intended for laboratory research and pharmaceutical manufacturing use. It must be handled by trained professionals in accordance with institutional safety protocols.
Assay (Anhydrous Basis) 95.0-105.0%
MAXIMUM LIMITS
Water 17.0%
Heavy Metals (as Pb) 0.005%
Residual Solvents To pass test
Chemical Storage Info
LIGHT SENSITIVE: Keep tightly closed in light-resistant containers
Chemical UPS Limit
150 lb
Health
1
Flammability
1
Chemical Category
FDA Regulated Items
Ensure the highest standard of pharmaceutical-grade chemical supply with Leucovorin Calcium, USP, manufactured by Spectrum Chemical. This vital reagent, also known as Calcium Folinate, is a derivative of folic acid used extensively in biochemical research and pharmaceutical formulation. As a USP Grade material, it is manufactured under stringent quality controls and meets the specific monographs established by the United States Pharmacopeia, ensuring it is suitable for food, drug, or medicinal use.
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Leucovorin Calcium, USP
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