Leucovorin Calcium, USP Grade
Manufacturer: Spectrum Chemical Manufacturing
Description
Leucovorin Calcium is primarily utilized in research related to oncology and cellular metabolism, acting as a potent biochemical modulator to "rescue" cells from the effects of methotrexate or to potentiate the activity of fluorouracil.
Technical Specifications:
- CAS Number: 1492-18-8
- Molecular Formula: C20H21CaN7O7
- Molecular Weight: 511.50 g/mol
- Appearance: White to pale yellow crystalline powder
- Solubility: Sparingly soluble in water; practically insoluble in alcohol
- Storage: Store at controlled room temperature (20°C to 25°C), protected from light and moisture
Application Insight:
In the laboratory environment, Leucovorin Calcium is used as:
- Folate Rescue Agent: To study the mechanisms of dihydrofolate reductase (DHFR) inhibition
- Potentiating Agent: In colorectal cancer research to stabilize the binding of fluorodeoxyuridylate to thymidylate synthase
- Standardization: As a reference standard for high-performance liquid chromatography (HPLC) and other analytical validation methods
Regulatory Note: This product is intended for laboratory research and pharmaceutical manufacturing use. It must be handled by trained professionals in accordance with institutional safety protocols.
| Ratings |
|---|
| Health1 |
| Flammability1 |
| Chemical CAS Number | 1492-18-8 |
|---|---|
| Chemical Formula | C20H21CaN7O7 |
| Chemical Formula Weight | F.W. 511.50 |
| Chemical Specs | Assay (Anhydrous Basis) 95.0-105.0% MAXIMUM LIMITS Water 17.0% Heavy Metals (as Pb) 0.005% Residual Solvents To pass test |
| Chemical Storage Info | LIGHT SENSITIVE: Keep tightly closed in light-resistant containers |
| Chemical UPS Limit | 150 lb |
| Health | 1 |
| Flammability | 1 |
| Chemical Category | FDA Regulated Items |
Starting at from $171.15 Sale $162.59
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